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Lidocaine is commonly added to the solution or applied topically

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For example, a recent study in 67 alcoholics who had sustained liver injury after paracetamol ingestion showed that 40% had taken less than 4 g/day (the maximum recommended therapeutic dose), whereas another 20% had taken between 4 and 6 g/day (which is also regarded as a non-toxic dose) (Zimmerman and Maddrey, 1995)